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G protein-coupled receptors (GPCRs) are integral membrane proteins with seven membrane-spanning helices. Upon binding to a ligand – which can range from small molecules like cyclic AMP to peptides and ...

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Crawford, K., Heatley, N. G., Boyd, P. F., Hale, C. W., Kelly, B. K., Miller, G. A., and Smith, N., J. Gen. Microbiol., 6, 47 (1952).

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