Explore 40 years of PCR history, from Kary Mullis’s invention story to the rise of digital PCR and how it revolutionized diagnostics and molecular biology.
Chronic hepatitis D virus (HDV) coinfection in people with chronic hepatitis B is associated with rapid progression to liver cirrhosis and high mortality. In 2020, the estimated global HDV burden ...
In 1869, Swiss scientist Friedrich Miescher isolated a mysterious substance from cell nuclei—an overlooked finding that would later reshape biology and our understanding of life itself. A ...
Every time a cell divides, it must copy its entire genome so that each daughter cell inherits a complete set of DNA. During that process, enzymes known as polymerases race along the DNA to copy its ...
Real-World Plasma Thymidine Kinase Activity in High-Risk and Metastatic Hormone Receptor–Positive, Human Epidermal Growth Factor Receptor 2–Negative Breast Cancer Treated With Cyclin-Dependent Kinase ...
Life's instructions are written in DNA, but it is the enzyme RNA polymerase II (Pol II) that reads the script, transcribing RNA in eukaryotic cells and eventually giving rise to proteins. Scientists ...
Simple, effective sample preparation workflows are needed that do not rely on traditional nucleic acid extraction methods to realize the promise of isothermal technologies like recombinase polymerase ...
A label-free nanopore platform uses programmable DNA circuits to build versatile molecular logic gates, forming a universal basis for scalable DNA computing and advanced biosensing applications.
Potential first-in-class, and industry-leading DNA polymerase Theta (Polθ) inhibitor, ART6043 demonstrated an attractive tolerability profile, expected PK/PD activity, and promising clinical signals ...
Is it the invasion of the genome snatchers? Just in case the idea of aliens walking around in human skin suits wasn’t frightening enough. An outlandish study asserts that aliens might have abducted us ...
We’re celebrating 180 years of Scientific American. Explore our legacy of discovery and look ahead to the future. In 1957, just four years after Francis Crick and other scientists solved the riddle of ...
The puzzle seems impossible: take a three-billion-letter code and predict what happens if you swap a single letter. The code we’re talking about—the human genome—stores most of its instructions in ...
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