Dr. Landen Discusses p53 Mutations in Ovarian Cancer | OncLive
Dr. Landen Discusses p53 Mutations in Ovarian Cancer | OncLive
1 week ago
onclive.com
Meet p53 — the “Guardian of the Genome.” 🧬✨ One tiny protein… with one huge job: protecting your cells from turning cancerous. When DNA gets damaged, p53 steps in like a strict supervisor: 🔍 Checks the damage 🛑 Stops the cell from dividing 🛠️ Attempts repairs ❌ And if the damage is too severe? p53 orders the cell to self-destruct to keep the rest of the body safe. That’s how powerful it is. The wild part? In many cancers, p53 is either mutated or shut off — meaning the body loses its top sec
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p53 is the guardian of the genome. p53 knockout mice (-/-) are highly susceptible to formation of tumors. why? failure to detect or accurately repair DNA damage can lead to oncogenesis, particularly if the mutations are in genes controlling the cell cycle, metabolism, and/or apoptosis #biochem #molecularbiology #oncogenesis #p53 #biotok #premed
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